ANALISIS KANDUNGAN ASAM RETINOAT PADA SEDIAAN KRIM MALAM YANG BEREDAR DI TOKO X KOTA KLATEN DENGAN SPEKTROFOTOMETRI UV-Vis

Anita Agustina Styawan; Choiril Hana Mustofa; Yenni Kusuma Wardhan

doi:10.61902/motorik.v15i1.39

Anita Agustina Styawan Program Studi DIII Farmasi STIKES Muhammadiyah Klaten
Choiril Hana Mustofa Program Studi DIII Farmasi STIKES Muhammadiyah Klaten
Yenni Kusuma Wardhan Program Studi DIII Farmasi STIKES Muhammadiyah Klaten

DOI: https://doi.org/10.61902/motorik.v15i1.39

Keywords: Retinoic Acid, Whitening Cream, UV-Vis Spectrophotometry

Abstract

Whitening cosmetics are cosmetics that contain an active whitening ingredient to brighten the skin. Retinoic acid is prohibited from being used in whitening creams because it can cause dry, burning, carcinogenic and teratogenic skin. The purpose of this study was to determine the levels of retinoic acid contained in night creams.

The sample in this study were 5 night cream products circulating in Klaten City X Store. This study was conducted to determine the content of retinoic acid in night creams using thin layer chromatography (TLC). Five positive samples contained retinoic acid by giving dark green spots and the concentration was determined by UV-Vis spectrophotometry.

The results of this study indicate that in 5 samples of night cream circulating in Store X in the City of Klaten all positive for retinoic acid, that is, the average for sample A was 0.021%; sample B 0.014%; sample C 0.016%; sample D 0.025% and sample E 0.023%.

Keywords: Retinoic Acid, Whitening Cream, UV-Vis Spectrophotometry

References

[1] Andriyani, V. B. Identifikasi Asam Retinoat Dalam Krim Pemutih Wajah Secara Kromatografi Lapis Tipis. Skripsi. Universitas Sumatra Utara. Medan. 2011.
[2] Anonim. Informatorium Obat Nasional Indonesia. Badan Pengawas Obat dan Makanan. Jakarta. 2008.
[3] Anonim. Peraturan Kepala Badan Pengawas Obat Dan Makanan Republik Indonesia Nomor HK.03.1.23.08.1107331 tahun 2011 tentang Metode Analisis Kosmetik. Jakarta. 2011.
[4] Azhara dan Khasanah, Nurul.. Waspada Bahaya Kosmetik. Flash Books. Yogyakarta. 2011
[5] Damayanti, M. E. Analisa Kualitatif Asam Retinoat Pada Sediaan Krim Malam Yang Beredar Di Pasar Klaten Dengan Metode Kromatografi Lapis Tipis. Karya Tulis Ilmiah. STIKES Muhammadiyah; Klaten. 2018.
[6] Day, R.A. dan Underwood, A. L.. Analisis Kimia Kuantitatif. Edisi Keenam. Penerbit Erlangga. Jakarta; 2002
[7] Gandjar, I. G. dan Rohman A. 2008. Kimia Farmasi Analisis. Pustaka Pelajar. Yogyakarta.
[8] Puspitadewi dan Retno. Efek Asam Retinoat yang Diberikan Pada Induk Mencit (Mus Musculus) Umur Bebuntingan 10 Hari Terhadap Hasil Reproduksi dan Kelainan Bawaan Ekternal Janin.Universitas Airlangga. Surabaya; 2008.
[9] Suhartini, Fatimawali, Gayatri Citraningtyas. Analisis Asam Retinoat Pada Kosmetik Krim Pemutih Yang Beredar Di Pasaran Kota Manado. Jurnal Ilmiah Farmasi. 2013. ISSN: 2302-2493.2 (1).2-5.
[10] Widana dan Yuningrat. Bahan Pewarna Berbahaya pada Sediaan Kosmetika Departemen Kesehatan. Jakarta; 2007.