IDENTIFIKASI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN TOBO-TOBO (Ficus septica Burm) TERHADAP BAKTERI ULKUS DIABETIK

Munifah Wahyuddin; Afrisusnawati Rauf; Nurshalati Tahar; Nurfitrah Syamsuddin; Huriyah Fadhilah

doi:10.61902/cerata.v15i2.1103

Munifah Wahyuddin UNIVERSITAS ISLAM NEGERI ALAUDDIN MAKASSAR
Afrisusnawati Rauf UIN Alauddin Makassar
Nurshalati Tahar UIN Alauddin Makassar
Nurfitrah Syamsuddin UIN Alauddin Makassar
Huriyah Fadhilah UIN Alauddin Makassar

DOI: https://doi.org/10.61902/cerata.v15i2.1103

Keywords: Daun tobo-tobo (Ficus septica Burm), Bakteri ulkus diabetik, Antibakteri, Alkaloid, Flavanoid, Saponin, Tanin

Abstract

People in Indonesia have long used tobo-tobo leaves (Ficus septica Burm). The ingredients contained in these leaves consist of alkaloid compounds, saponins, flavonoids, and tannins, which are compounds that are antibacterial, so they have the potential to be developed as plants. drug. This study aims to determine the antibacterial activity of the ethanol extract of tobo-tobo leaves against diabetic ulcer bacteria, namely Pseudomonas aeruginosa, Providencia stuartii, Citrobacter freundii, Pseudomonas luteola, Burkholderia cepacia, Acinetobacter baumannii, and Proteus merabilis. For this kind of research, a quantitative experimental method is used. The ethanol solvent is used for extraction, and the agar diffusion method on NA medium is used to test for bacteria. The test showed that the tobo-tobo (Ficus septica Burm) leaf extract made of ethanol had alkaloids, saponins, flavonoids, and tannins in it. In the antibacterial activity test on each extract with a concentration of 20%, 40%, 60%, 80%, and 100%, it was found that the ethanol extract of tobo-tobo leaves at a concentration of 100% gave the greatest antibacterial effect on bacterial growth with an average diameter value of flat. average: Pseudomonas aeruginosa 12.8 mm (strong), Providencia stuartii 9.33 mm (medium), Citrobacter freundii 11.83 mm (strong), Pseudomonas luteola 11 mm (strong), Burkholderia cepacian 10.16 mm (strong), Acinetobacter baumannii 9.5 mm (moderate), and Proteus merabilis 6.5 mm (moderate).

References

itria, E. et al. (2017) ‘Karakteristik Ulkus Diabetikum pada Penderita Diabetes Melitus di RSUD dr. Zainal Abidin dan RSUD Meraxa Banda Aceh’, Buletin dan Penelitian Kesehatan [Preprint]
Fradianto, I. (2022) ‘Identifikasi Bakteri Pada Luka Kaki Diabetes Yang Mengalami Infeksi: Kajian Identification Of Bacteria In Infected Diabetic Foot Ulcer’, Literatur Review. Berkala Ilmiah Mahasiswa Ilmu Keperawatan Indonesia [Preprint].
Kurniawan, E. et al. (2019) ‘Aktivitas Antibakteri Ekstrak Metanol Batang Bidara Laut (Strychnos ligustriana) Terhadap Bakteri Patogen’, Jurnal Biologi Tropis [Preprint].
LRH, D. et al. (2016) ‘Uji Aktivitas Antibakteri Ekstrak Daun Kelor (Moringa Oleufera L.) Terhadap Bakteri Escherichia coli Dan Staphylococcus aureus’, PHARMACON Jurnal Ilmiah Farmasi UNSRAT, 5(2).
Makalew, M.A.J. et al. (2016) ‘Uji Efek Antibakteri Air Perasan Daging Buah Nanas (Annans Comsus (L) Merr) Terhadap Bakteri Klebsiella pneumoniae’, In Jurnal e-Biomedik (eBm), 4(1).
Mu’Nisa, A. et al. (2018) ‘Bioactive compound and Antioxidant Activity Analysis of Some Medicinal Plants of Province of Westtern Sulawesi’, Journal of Physics [Preprint].
Nufus, I. et al. (2021) ‘Aktivitas Antidiabetik Ekstrak Daun Sawo Manila Terhadap Kadar Gula Darah dan Penyembuhan Ulkus Mencit Diabetes’, Journal Unesa [Preprint].
Siregar, S. (2017) Statistika Terapan Untuk Perguruan Tinggi. Prenada Media.
Sulistyarini, I. et al. (2020) ‘Skrining Fitokimia Senyawa Metabolit Sekunder Batang Buah Naga (Hylocereus polyrhizus)’.
Wahyuni et al. (2021) ‘Biodiversitas Flora Dan Fauna Pantai Biluhu Timur (Suatu Tinjauan Ekologi-Lingkungan Pantai)’, Deepublish [Preprint].
Winastri, N.L.A. et al. (2020) ‘Aktivitas Antibakteri Air Perasan dan Rebusan Daun Calincing (Oxalis coniculata L.)